BDBM50327243 CHEMBL1257577::endo-3-(8-(thiophen-2-ylmethyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES NC(=O)c1cccc(O[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2cccs2)c1

InChI Key InChIKey=KNKVLWDIKQGTIB-SCAQPMJSSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327243   

TargetDelta-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327243(CHEMBL1257577 | endo-3-(8-(thiophen-2-ylmethyl)-8-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at human delta opioid receptor assessed as inhibition of SNC80-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327243(CHEMBL1257577 | endo-3-(8-(thiophen-2-ylmethyl)-8-...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327243(CHEMBL1257577 | endo-3-(8-(thiophen-2-ylmethyl)-8-...)
Affinity DataIC50:  215nMAssay Description:Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327243(CHEMBL1257577 | endo-3-(8-(thiophen-2-ylmethyl)-8-...)
Affinity DataIC50:  9.36E+3nMAssay Description:Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed