BDBM50327605 6-(4-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)butoxy)isoindolin-1-one::CHEMBL1258879

SMILES Fc1cccc2cccc(N3CCN(CCCCOc4ccc5CNC(=O)c5c4)CC3)c12

InChI Key InChIKey=NNTYWLSMUTYNRH-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50327605   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327605(6-(4-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)bu...)
Affinity DataKi:  0.0504nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327605(6-(4-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)bu...)
Affinity DataKi:  0.951nMAssay Description:Binding affinity to human 5HT1A receptor expressed in HeLa cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327605(6-(4-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)bu...)
Affinity DataKi:  1.83nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327605(6-(4-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)bu...)
Affinity DataKi:  3.18nMAssay Description:Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327605(6-(4-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)bu...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-citalopram from human serotonin transporter expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327605(6-(4-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)bu...)
Affinity DataKi:  2.06E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed