BDBM50328187 CHEMBL1257426::N-ethyl-4-(4-(trifluoromethoxy)phenylamino)thieno[2,3-d]pyrimidine-6-carboxamide::US9670214, TABLE 13.5

SMILES CCNC(=O)c1cc2c(Nc3ccc(OC(F)(F)F)cc3)ncnc2s1

InChI Key InChIKey=ZXJCTVGWBHRFOZ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328187   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50328187(CHEMBL1257426 | N-ethyl-4-(4-(trifluoromethoxy)phe...)
Affinity DataEC50:  918nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328187(CHEMBL1257426 | N-ethyl-4-(4-(trifluoromethoxy)phe...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetNon-specific protein-tyrosine kinase(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328187(CHEMBL1257426 | N-ethyl-4-(4-(trifluoromethoxy)phe...)
Affinity DataIC50:  918nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent