BDBM50328198 2-(4-(4-(Trifluoromethoxy)phenylamino)-1H-pyrazolo-[3,4-d]pyrimidin-1-yl)ethanol::CHEMBL1258010::US9670214, TABLE 10.7

SMILES OCCn1ncc2c(Nc3ccc(OC(F)(F)F)cc3)ncnc12

InChI Key InChIKey=QQDDFQKWZHOVDY-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328198   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50328198(2-(4-(4-(Trifluoromethoxy)phenylamino)-1H-pyrazolo...)
Affinity DataEC50:  250nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-specific protein-tyrosine kinase [T818I](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328198(2-(4-(4-(Trifluoromethoxy)phenylamino)-1H-pyrazolo...)
Affinity DataIC50:  4.20E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-specific protein-tyrosine kinase(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328198(2-(4-(4-(Trifluoromethoxy)phenylamino)-1H-pyrazolo...)
Affinity DataIC50:  254nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent