BDBM50328585 1-(4-(4-([3,6'-Biquinolin]-4'-ylamino)-2-(trifluoromethyl)phenyl)-piperazin-1-yl)ethanone::CHEMBL1258995

SMILES OC(=O)N1CCN(CC1)c1ccc(Nc2ccnc3ccc(cc23)-c2cnc3ccccc3c2)cc1C(F)(F)F

InChI Key InChIKey=UZUVRFUOLOBORV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328585   

TargetSerine/threonine-protein kinase mTOR(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328585(1-(4-(4-([3,6'-Biquinolin]-4'-ylamino)-2-(trifluor...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human mTOR complex 1 after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328585(1-(4-(4-([3,6'-Biquinolin]-4'-ylamino)-2-(trifluor...)
Affinity DataIC50: >300nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells expressing Akt1 S473D mutant assessed as phosphorylation of Akt Thr308 by immunoblottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Mouse)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328585(1-(4-(4-([3,6'-Biquinolin]-4'-ylamino)-2-(trifluor...)
Affinity DataIC50: >300nMAssay Description:Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed