BDBM50329219 CHEMBL1270999::N-(3,5-dimethylphenyl)-2-(4-(trifluoromethoxy)phenyl)thiazole-4-carboxamide

SMILES Cc1cc(C)cc(NC(=O)c2csc(n2)-c2ccc(OC(F)(F)F)cc2)c1

InChI Key InChIKey=SQMRGZVDASANKI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50329219   

TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329219(CHEMBL1270999 | N-(3,5-dimethylphenyl)-2-(4-(trifl...)
Affinity DataIC50:  380nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329219(CHEMBL1270999 | N-(3,5-dimethylphenyl)-2-(4-(trifl...)
Affinity DataIC50:  400nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329219(CHEMBL1270999 | N-(3,5-dimethylphenyl)-2-(4-(trifl...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed