BDBM50329914 1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272140

SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1

InChI Key InChIKey=VEFDUZNTHFBSFU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50329914   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  1nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  3.52E+3nMAssay Description:Inhibition of PLK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  3.52E+3nMAssay Description:Inhibition of PLK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of NEK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed