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BDBM50330738 2-(2-chloro-4-fluorophenyl)-5-(2-(pyridin-2-yl)ethyl)-4-(pyrrolidin-1-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1277676

SMILES: Fc1ccc(c(Cl)c1)-n1[nH]c2cc(=O)n(CCc3ccccn3)c(CN3CCCC3)c2c1=O

InChI Key: InChIKey=KDLREDKHWFPVCT-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50330738   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADPH oxidase 4


(Homo sapiens)
BDBM50330738
PNG
(2-(2-chloro-4-fluorophenyl)-5-(2-(pyridin-2-yl)eth...)
Show SMILES Fc1ccc(c(Cl)c1)-n1[nH]c2cc(=O)n(CCc3ccccn3)c(CN3CCCC3)c2c1=O
Show InChI InChI=1S/C24H23ClFN5O2/c25-18-13-16(26)6-7-20(18)31-24(33)23-19(28-31)14-22(32)30(12-8-17-5-1-2-9-27-17)21(23)15-29-10-3-4-11-29/h1-2,5-7,9,13-14,28H,3-4,8,10-12,15H2
KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
114n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair