BDBM50330739 2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)-5-(pyridin-4-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1277677

SMILES CN(Cc1n(Cc2ccncc2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12)c1ccccc1

InChI Key InChIKey=JBMFBKALKQFKHF-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50330739   

TargetNADPH oxidase 4(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330739(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Affinity DataKi:  151nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330739(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330739(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330739(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330739(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed