BDBM50331032 (R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one::CHEMBL1277072

SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCCN(C[C@H](O)CN3CCOCC3)C(=O)c12

InChI Key InChIKey=MCTXSDCWFQAGFS-UEXNTNOUSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331032   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331032((R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-yliden...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human VEGFR2 after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331032((R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-yliden...)
Affinity DataIC50:  26nMAssay Description:Inhibition of VEGFR2-induced cell proliferation in HUVEC after 72 hrs by sulforhodamine B methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331032((R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-yliden...)
Affinity DataIC50:  8nMAssay Description:Inhibition of c-Kit after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331032((R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-yliden...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human PDGFRbeta after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed