BDBM50331143 2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)nicotinamide::CHEMBL1290146::US9422293, 294::US9738649, Example 294

SMILES NC(=O)c1cccnc1N1CCc2ncnc(Nc3ccc(cc3)C(F)(F)F)c2CC1

InChI Key InChIKey=LOAYGWDGCQXPQT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331143   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331143(2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-...)
Affinity DataIC50:  3.39E+3nMT: 37°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM50331143(2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-...)
Affinity DataIC50:  2.94E+3nMT: 37°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM50331143(2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-...)
Affinity DataIC50:  2.94E+3nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331143(2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-...)
Affinity DataIC50:  3.39E+3nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331143(2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-...)
Affinity DataIC50:  2.36E+3nMAssay Description:Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed