BDBM50331292 (+/-)-cis-3-(4-Phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol::CHEMBL1289837

SMILES OC1CN(CCc2cc(O)ccc12)[C@H]1CC[C@H](CC1)c1ccccc1

InChI Key InChIKey=GUYOIYKANZNIKE-RYKNDIGVSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50331292   

TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Institut FüR Pharmazeutische Und Medizinische Chemie Der WestfäLischen Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM50331292((+/-)-cis-3-(4-Phenylcyclohexyl)-2,3,4,5-tetrahydr...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische Und Medizinische Chemie Der WestfäLischen Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM50331292((+/-)-cis-3-(4-Phenylcyclohexyl)-2,3,4,5-tetrahydr...)
Affinity DataKi:  123nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor guinea pig brain after 180 mins scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Institut FüR Pharmazeutische Und Medizinische Chemie Der WestfäLischen Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM50331292((+/-)-cis-3-(4-Phenylcyclohexyl)-2,3,4,5-tetrahydr...)
Affinity DataIC50:  1.21E+4nMAssay Description:Antagonist activity at human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells assessed as inhibition of (S)-glutamate/glycine-stimula...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed