BDBM50331946 CHEMBL1289345::N-(1-Adamantyl)-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidine-3-carboxamide

SMILES FC(F)(F)[C@H]1C[C@H](Nc2c(cnn12)C(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1

InChI Key InChIKey=YXUXTGVWZCXDOV-ZJJNMPENSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50331946   

TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331946(CHEMBL1289345 | N-(1-Adamantyl)-5-phenyl-7-(triflu...)
Affinity DataIC50:  40nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331946(CHEMBL1289345 | N-(1-Adamantyl)-5-phenyl-7-(triflu...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed