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BDBM50332949 (R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)propanamide::CHEMBL1632639

SMILES: COc1ccc(cc1)S(=O)(=O)N[C@H](CO)C(=O)NO

InChI Key: InChIKey=PCRITYAGTCCZEK-SECBINFHSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332949   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (human))
BDBM50332949
PNG
((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](CO)C(=O)NO
Show InChI InChI=1S/C10H14N2O6S/c1-18-7-2-4-8(5-3-7)19(16,17)12-9(6-13)10(14)11-15/h2-5,9,12-13,15H,6H2,1H3,(H,11,14)/t9-/m1/s1
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Article
PubMed
2.20n/an/an/an/an/an/an/an/a



ProtEra s.r.l.

Curated by ChEMBL


Assay Description
Inhibition of MMP13 by fluorimetric assay


Eur J Med Chem 45: 5919-25 (2010)


Article DOI: 10.1016/j.ejmech.2010.09.057
BindingDB Entry DOI: 10.7270/Q29G5N2W
More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50332949
PNG
((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](CO)C(=O)NO
Show InChI InChI=1S/C10H14N2O6S/c1-18-7-2-4-8(5-3-7)19(16,17)12-9(6-13)10(14)11-15/h2-5,9,12-13,15H,6H2,1H3,(H,11,14)/t9-/m1/s1
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6n/an/an/an/an/an/an/an/a



ProtEra s.r.l.

Curated by ChEMBL


Assay Description
Inhibition of MMP12 by fluorimetric assay


Eur J Med Chem 45: 5919-25 (2010)


Article DOI: 10.1016/j.ejmech.2010.09.057
BindingDB Entry DOI: 10.7270/Q29G5N2W
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50332949
PNG
((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](CO)C(=O)NO
Show InChI InChI=1S/C10H14N2O6S/c1-18-7-2-4-8(5-3-7)19(16,17)12-9(6-13)10(14)11-15/h2-5,9,12-13,15H,6H2,1H3,(H,11,14)/t9-/m1/s1
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9n/an/an/an/an/an/an/an/a



ProtEra s.r.l.

Curated by ChEMBL


Assay Description
Inhibition of MMP8 by fluorimetric assay


Eur J Med Chem 45: 5919-25 (2010)


Article DOI: 10.1016/j.ejmech.2010.09.057
BindingDB Entry DOI: 10.7270/Q29G5N2W
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50332949
PNG
((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](CO)C(=O)NO
Show InChI InChI=1S/C10H14N2O6S/c1-18-7-2-4-8(5-3-7)19(16,17)12-9(6-13)10(14)11-15/h2-5,9,12-13,15H,6H2,1H3,(H,11,14)/t9-/m1/s1
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143n/an/an/an/an/an/an/an/a



ProtEra s.r.l.

Curated by ChEMBL


Assay Description
Inhibition of MMP1 by fluorimetric assay


Eur J Med Chem 45: 5919-25 (2010)


Article DOI: 10.1016/j.ejmech.2010.09.057
BindingDB Entry DOI: 10.7270/Q29G5N2W
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50332949
PNG
((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](CO)C(=O)NO
Show InChI InChI=1S/C10H14N2O6S/c1-18-7-2-4-8(5-3-7)19(16,17)12-9(6-13)10(14)11-15/h2-5,9,12-13,15H,6H2,1H3,(H,11,14)/t9-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
823n/an/an/an/an/an/an/an/a



ProtEra s.r.l.

Curated by ChEMBL


Assay Description
Inhibition of MMP7 by fluorimetric assay


Eur J Med Chem 45: 5919-25 (2010)


Article DOI: 10.1016/j.ejmech.2010.09.057
BindingDB Entry DOI: 10.7270/Q29G5N2W
More data for this
Ligand-Target Pair