BDBM50334764 CHEMBL1642894::trans-(2R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-2-amine

SMILES CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc2C1

InChI Key InChIKey=KDERKEZKMQCRPQ-ZFWWWQNUSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50334764   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  27nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  114nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  67nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed