BDBM50335104 3-(5-Amino-[1,3,4]thiadiazol-2-yl)-1-(thiophen-2-yl)propan-1-one::CHEMBL1650287

SMILES Nc1nnc(CCC(=O)c2cccs2)s1

InChI Key InChIKey=ODSWRTIXISBLTP-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335104   

TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335104(3-(5-Amino-[1,3,4]thiadiazol-2-yl)-1-(thiophen-2-y...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Leishmania major PTR1 by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Human)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335104(3-(5-Amino-[1,3,4]thiadiazol-2-yl)-1-(thiophen-2-y...)
Affinity DataIC50:  3.00E+5nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335104(3-(5-Amino-[1,3,4]thiadiazol-2-yl)-1-(thiophen-2-y...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of Leishmania major PTR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335104(3-(5-Amino-[1,3,4]thiadiazol-2-yl)-1-(thiophen-2-y...)
Affinity DataIC50:  1.39E+5nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed