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BDBM50337145 9-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one::CHEMBL1673057

SMILES: COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccc(Cl)cc3N(C)c2n1)N1CCN(C)CC1

InChI Key: InChIKey=RHSOYHKODVPGTH-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50337145   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 7


(Homo sapiens)
BDBM50337145
PNG
(9-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Show SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccc(Cl)cc3N(C)c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C25H28ClN7O2/c1-30-9-11-33(12-10-30)17-6-8-19(22(14-17)35-4)28-25-27-15-21-23(29-25)31(2)20-13-16(26)5-7-18(20)24(34)32(21)3/h5-8,13-15H,9-12H2,1-4H3,(H,27,28,29)
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Similars

Article
PubMed
n/an/a 1.14E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis


ACS Med Chem Lett 2: 195-200 (2011)

More data for this
Ligand-Target Pair