BDBM50338311 (+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-5-yl)but-3-en-2-one::CHEMBL1682430

SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=CC(C)=O)c12)-c1cccc2cc[nH]c12

InChI Key InChIKey=AZZFDTTVGWXWEX-UPCLLVRISA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50338311   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338311((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Affinity DataKi:  10.4nMAssay Description:Displacement of radiolabeled dexamethasone from GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338311((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Affinity DataEC50:  112nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338311((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Affinity DataIC50: >1.00E+3nMAssay Description:Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338311((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Affinity DataIC50:  7.80nMAssay Description:Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed