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BDBM50339134 3-(2-Chloro-phenothiazin-10-yl)-propylamine::3-(2-chloro-10H-phenothiazin-10-yl)propan-1-amine::CHEMBL824::Nor2-Chlorpromazine

SMILES: NCCCN1c2ccccc2Sc2ccc(Cl)cc12

InChI Key: InChIKey=ZTQZBABFEUDZFE-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339134   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Pleiotropic ABC efflux transporter of multiple drugs


(Saccharomyces cerevisiae S288c)
BDBM50339134
PNG
(3-(2-Chloro-phenothiazin-10-yl)-propylamine | 3-(2...)
Show SMILES NCCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C15H15ClN2S/c16-11-6-7-15-13(10-11)18(9-3-8-17)12-4-1-2-5-14(12)19-15/h1-2,4-7,10H,3,8-9,17H2
KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Similars

Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



Wroclaw Medical University

Curated by ChEMBL


Assay Description
Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay


Antimicrob Agents Chemother 53: 1516-27 (2009)

More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)
BDBM50339134
PNG
(3-(2-Chloro-phenothiazin-10-yl)-propylamine | 3-(2...)
Show SMILES NCCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C15H15ClN2S/c16-11-6-7-15-13(10-11)18(9-3-8-17)12-4-1-2-5-14(12)19-15/h1-2,4-7,10H,3,8-9,17H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.39E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase


J Med Chem 41: 148-56 (1998)

More data for this
Ligand-Target Pair