BDBM50340012 6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H-1,2,4-triazol-3-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one::CHEMBL1762504

SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12

InChI Key InChIKey=XMXPDOACJPQJLR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50340012   

TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340012(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340012(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Affinity DataIC50:  9.14E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340012(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]dapagliflozin from human SGLT2 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340012(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/myo-inositol cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340012(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Affinity DataIC50:  1.44E+4nMAssay Description:Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed