BDBM50340663 5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-isopropyl oxime::CHEMBL1762204
SMILES CC(C)O\N=C1/CC(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2c(C)c[nH]c12
InChI Key InChIKey=NLDACKJWSTTYSC-MTDXEUNCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50340663
Affinity DataKi: 2.70nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataKi: 380nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.80E+3nMAssay Description:Binding affinity to mineralocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with PEPCK assessed as GRE activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Transrepression activity at glucocorticoid receptor in human NHDF cells assessed as inhibition of IL-1beta-stimulated AP1 dependent IL-6 repression b...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Transrepression activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of TNFalpha/IL1beta-stimulated NFkappaB-dependent E-s...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as GRE activation by luciferase reporter gene assayMore data for this Ligand-Target Pair