BDBM50340857 CHEMBL1761615::N-(2-(5-chloro-1H-indole-2-carboxamido)phenyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide

SMILES: CN1CCc2nc(sc2C1)C(=O)Nc1ccccc1NC(=O)c1cc2cc(Cl)ccc2[nH]1

InChI Key: InChIKey=HLZHKMHNSZRIOD-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340857   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50340857 (CHEMBL1761615 | N-(2-(5-chloro-1H-indole-2-carboxa...) Show SMILES CN1CCc2nc(sc2C1)C(=O)Nc1ccccc1NC(=O)c1cc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C23H20ClN5O2S/c1-29-9-8-18-20(12-29)32-23(28-18)22(31)27-17-5-3-2-4-16(17)26-21(30)19-11-13-10-14(24)6-7-15(13)25-19/h2-7,10-11,25H,8-9,12H2,1H3,(H,26,30)(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysis				Bioorg Med Chem Lett 21: 2133-40 (2011) Article DOI: 10.1016/j.bmcl.2011.01.132 BindingDB Entry DOI: 10.7270/Q2MK6D60
					More data for this Ligand-Target Pair				3D Structure (crystal)