BDBM50341075 (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyphenyl)piperazin-1-yl)methanone::CHEMBL1760338

SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1

InChI Key InChIKey=DEYOMMQLWMIBRN-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50341075   

TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataKi:  250nMAssay Description:Displacement [3H]SB-222200 from of human recombinant NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Rattus norvegicus)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataKi:  250nMAssay Description:Binding affinity to rat NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataKi:  8.00E+3nMAssay Description:Binding affinity to human NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341075((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed