BDBM50341257 5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-2-phenylthiazol-4(5H)-one::CHEMBL1765887

SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccccc2)cc(c1O)[N+]([O-])=O

InChI Key InChIKey=XBTFLDWDXOUUKS-ZROIWOOFSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341257   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341257(5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-2-pheny...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341257(5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-2-pheny...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341257(5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-2-pheny...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341257(5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-2-pheny...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed