BDBM50341730 3-amino-6-(3-chlorophenyl)-N-phenylpyrazine-2-carboxamide::CHEMBL1766776

SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1cccc(Cl)c1

InChI Key InChIKey=HPOWNJBVIBEXQY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341730   

TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341730(3-amino-6-(3-chlorophenyl)-N-phenylpyrazine-2-carb...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341730(3-amino-6-(3-chlorophenyl)-N-phenylpyrazine-2-carb...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341730(3-amino-6-(3-chlorophenyl)-N-phenylpyrazine-2-carb...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed