BDBM50342278 (2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone::Benzarone::CHEMBL1474963::US9725430, Compound 1a::US9962362, Compound 1a

SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1

InChI Key InChIKey=RFRXIWQYSOIBDI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50342278   

TargetSolute carrier family 22 member 12(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEyes absent homolog 3 [223-510](Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50:  1.92E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEyes absent homolog 3(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50:  1.70E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50: >1.50E+5nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEyes absent homolog 3 [223-510](Mus musculus (Mouse))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50:  1.92E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEyes absent homolog 3(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50:  1.70E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50: >1.50E+5nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In DepthDetails US Patent