BDBM50342570 (E)-4-bromo-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one::CHEMBL1770539

SMILES Brc1cccc2NC(=O)\C(=C\C(=O)c3cccnc3)c12

InChI Key InChIKey=GGFKPYBOYPQZEI-JXMROGBWSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50342570   

TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))
Stanford University

Curated by ChEMBL
LigandPNGBDBM50342570((E)-4-bromo-3-(2-oxo-2-(pyridin-3-yl)ethylidene)in...)
Affinity DataKi:  250nMAssay Description:Inhibition of human transglutaminase 2 using ZGBC as a substrate after 30 to 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))
Stanford University

Curated by ChEMBL
LigandPNGBDBM50342570((E)-4-bromo-3-(2-oxo-2-(pyridin-3-yl)ethylidene)in...)
Affinity DataKi:  400nMAssay Description:Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))
Stanford University

Curated by ChEMBL
LigandPNGBDBM50342570((E)-4-bromo-3-(2-oxo-2-(pyridin-3-yl)ethylidene)in...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human transglutaminase 2 using ZGBC as a substrate after 30 to 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))
Stanford University

Curated by ChEMBL
LigandPNGBDBM50342570((E)-4-bromo-3-(2-oxo-2-(pyridin-3-yl)ethylidene)in...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed