BDBM50343081 CHEMBL1771216::N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-2H-tetrazol-2-yl)propoxy)phenylsulfonyl)piperidine-4-carboxamide

SMILES COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(OCCCn2nnc(n2)-c2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=MTRATHZFTCSGDT-UHFFFAOYSA-N

Data  8 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50343081   

TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  80nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  160nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  230nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  8.60E+3nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed