BDBM50343137 CHEMBL1770313::Cyclomorusin::Cycolmorusin, 2

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12

InChI Key InChIKey=GDQXJMLXEYSICD-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50343137   

TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

LigandPNGBDBM50343137(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Affinity DataKi:  46.4nM ΔG°:  -10.2kcal/moleT: 2°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50343137(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

LigandPNGBDBM50343137(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Affinity DataIC50:  1.61E+5nMT: 2°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50343137(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Affinity DataIC50:  1.01E+5nMAssay Description:Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50343137(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of BuChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

LigandPNGBDBM50343137(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Affinity DataIC50:  9.16E+4nMT: 2°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed