BDBM50344569 CHEMBL1778447::N-(4-bromo-6-(3-methylureido)pyridin-2-ylcarbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
SMILES: CNC(=O)Nc1cc(Br)cc(NC(=O)NS(=O)(=O)c2cc(C)c(CCOC)s2)n1
InChI Key: InChIKey=OKYOPMCSUZGIPB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fructose-1,6-bisphosphatase 1 (Mus musculus) | BDBM50344569![]() (CHEMBL1778447 | N-(4-bromo-6-(3-methylureido)pyrid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc Curated by ChEMBL | Assay Description Inhibition of mouse liver fructose-1,6-bisphosphatase | Bioorg Med Chem Lett 21: 3237-42 (2011) Article DOI: 10.1016/j.bmcl.2011.04.044 BindingDB Entry DOI: 10.7270/Q2C24WS9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (FBPase) (Homo sapiens (Human)) | BDBM50344569![]() (CHEMBL1778447 | N-(4-bromo-6-(3-methylureido)pyrid...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc Curated by ChEMBL | Assay Description Inhibition of human liver fructose-1,6-bisphosphatase | Bioorg Med Chem Lett 21: 3237-42 (2011) Article DOI: 10.1016/j.bmcl.2011.04.044 BindingDB Entry DOI: 10.7270/Q2C24WS9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |