BDBM50345727 1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1785014::US10544104, Compound 7e::US11247972, Compound 7e::US9765037, Compound 7e

SMILES CC(C)c1cccc(c1)-c1nn(C(C)C)c2ncnc(N)c12

InChI Key InChIKey=GZTMFOCEFPOHGW-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50345727   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Toxoplasma gondii recombinant N-terminal hexahistidine tagged CDPK1 expressed in Escherichia coli using syntide-2 as substrate after 90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  59nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  14nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  59nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  59nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  220nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  59nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  14nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  200nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  220nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM50345727(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent