BDBM50345732 1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1242847::CHEMBL2069942::US10544104, Compound 7j::US11247972, Compound 7j::US9765037, Compound 7j

SMILES COc1ccc(cc1)-c1nn(C(C)C)c2ncnc(N)c12

InChI Key InChIKey=DUPSNQFPAJUAKA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50345732   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Toxoplasma gondii recombinant N-terminal hexahistidine tagged CDPK1 expressed in Escherichia coli using syntide-2 as substrate after 90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphorimaging methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  40nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  410nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  410nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  410nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  410nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  40nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  40nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345732(1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  40nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent