BDBM50349984 CHEMBL1813048
SMILES CC(=O)Nc1cccc(Nc2ncnc(n2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
InChI Key InChIKey=QLKAFHZJICDACE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50349984
Affinity DataKi: 35nMAssay Description:Binding affinity to inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Displacement of [3H]N-(3-(4-(4-(Benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)-phenyl)acetamide from human Nav1.7 expressed in human HEK293 cells...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]BTX from human Nav1.7 expressed in human HEK293 cells after 1 hr by MicroBeta analyzerMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of 20% inactivated TTX-resistant human sodium channel Nav1.3 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological a...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of fully inactivated TTX-resistant human sodium channel Nav1.4 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay in presence of 5%...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Erg expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat P2X7 by fluorescent-based live-cell assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human TRPM8 by fluorescent-based live-cell assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TRPV4 by fluorescent-based live-cell assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TRPV3 by fluorescent-based live-cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of 20% inactivated TTX-resistant human sodium channel Nav1.4 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological a...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >3.33E+4nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of fully inactivated TTX-resistant human sodium channel Nav1.3 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of 20% inactivated TTX-resistant rat sodium channel Nav1.8 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of 20% inactivated TTX-resistant human sodium channel Nav1.5 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological a...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of fully inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human cardiac sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of fully inactivated TTX-resistant human sodium channel Nav1.5 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological...More data for this Ligand-Target Pair