BindingDB PrimarySearch

BDBM50355393 CHEMBL1834657::US9434697, BGJ398

SMILES: CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1

InChI Key: InChIKey=QADPYRIHXKWUSV-UHFFFAOYSA-N

Data: 108 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 108 hits for monomerid = 50355393
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PLK1				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Protein kinase N2 (Homo sapiens)	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PKN2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Protein kinase N1 (Homo sapiens)	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PKN1				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PKCtheta				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
AKT/p21CIP1 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PKBalpha				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PIM (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PIM2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kbeta by luminescent kinase assay				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
PI3-kinase subunit delta (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kdelta by luminescent kinase assay				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
PI3-kinase subunit alpha (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kalpha				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant JAK1				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant IRAK4				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant IGF1R				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
SRC (Homo sapiens)	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant HCK				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant GSK3-beta				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant FAK				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4) (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant EPHB4				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Ephrin receptor (Homo sapiens)	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant EPHA4				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
MAP kinase ERK2 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant ERK2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (HER4) (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant ERBB4				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant ERBB2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant EGFR				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant CSK				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Casein kinase I isoform gamma-3 (Homo sapiens)	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant CK1-gamma3				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant CDK4				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant CDK2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant BTK				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
p38 delta/gamma (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant p38-gamma				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant p38alpha				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
p21-Activated kinase 2 (PAK2) (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant PAK2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant mTOR by luminescent kinase assay				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
MAP kinase signal-integrating kinase 2 (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant MNK2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant MNK1				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 5 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant MK5				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant MK2				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera (Homo sapiens)	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant MER				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant JAK3				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
AXL receptor tyrosine kinase (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant AXL				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant Aurora A				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant ALK				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of wild type FGFR2 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 1 (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of wild type FGFR1 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of VEGFR1 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant YES kinase				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant LYN kinase				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
SRC (Homo sapiens (human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant LCK kinase				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit) (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant KIT kinase				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
SRC (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant FYN kinase				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant ABL kinase				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR4				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50355393 (CHEMBL1834657 \| US9434697, BGJ398) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR3				J Med Chem 54: 7066-83 (2011)
					More data for this Ligand-Target Pair

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