BDBM50356445 CHEMBL1911701

SMILES O=c1[nH]c(SCc2cccnc2C#N)c2COCCc2c1C#N

InChI Key InChIKey=RMZOHPFYZBRDJW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50356445   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50356445(CHEMBL1911701)
Affinity DataIC50:  12nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50356445(CHEMBL1911701)
Affinity DataIC50:  270nMAssay Description:Inhibition of 11beta-HSD1 in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50356445(CHEMBL1911701)
Affinity DataIC50:  3.97E+3nMAssay Description:Inhibition of 11beta-HSD1 in mouse 3T3L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50356445(CHEMBL1911701)
Affinity DataIC50:  105nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed