BDBM50357828 CHEMBL1915912
SMILES COc1ccc2nc(C)c3c(C)nc(-c4sc(C)nc4C)n3c2n1
InChI Key InChIKey=FHILGPQALCJBPN-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50357828
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 5.09E+3nMAssay Description:Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.28E+3nMAssay Description:Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 824nMAssay Description:Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair