BDBM50359196 CHEMBL1923158

SMILES CN1CC(N)=NC(C)(C1=O)c1cccc(NC(=O)c2ccc(Cl)cn2)c1

InChI Key InChIKey=MRYFMHAPTQCQLE-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50359196   

TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359196(CHEMBL1923158)
Affinity DataIC50:  78nMAssay Description:Inhibition of human BACE1-mediated amyloid beta TOT secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359196(CHEMBL1923158)
Affinity DataIC50:  447nMAssay Description:Inhibition of human recombinant BACE1 using fluorescent Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH peptide as substrate after 1 hr by spectr...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359196(CHEMBL1923158)
Affinity DataIC50:  98nMAssay Description:Inhibition of human BACE1-mediated amyloid beta 42 secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair