BDBM50363564 CHEMBL1946851

SMILES Fc1c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c(F)c1NC(=O)c1no[nH]c1=O

InChI Key InChIKey=CGEIKBLLWKMFGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50363564   

TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Torino

Curated by ChEMBL
LigandPNGBDBM50363564(CHEMBL1946851)
Affinity DataIC50:  599nMAssay Description:Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50363564(CHEMBL1946851)
Affinity DataIC50:  50nMAssay Description:Inhibition of dihydroorotate dehydrogenase in Wistar rat liver mitochondrial/microsomal membranes measured for 5 mins by 2,6-dichlorophenolindophenol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed