BDBM50364033 CHEMBL1224151

SMILES COc1cc(\C=C2/CCCN([C@@H](C)c3ccc(F)cc3)C2=O)ccc1-n1cnc(C)c1

InChI Key InChIKey=PUOAETJYKQITMO-LANLRWRYSA-N

Data  8 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50364033   

LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  85nMAssay Description:Modulation of gamma-secretase in HEK293 cells expressing Swedish mutant APP assessed as inhibition of intracellular amyloid beta 42 production after ...More data for this Ligand-Target Pair
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  560nMAssay Description:Modulation of gamma-secretase in HEK293 cells expressing Swedish mutant APP assessed as inhibition of intracellular amyloid beta 40 production after ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human ERG by cell based voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  80nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as reduction in amyloid beta 42 levelMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  64nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  64nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells by sandwich immunoassayMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  64nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cellsMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataEC50:  83nMAssay Description:Modulation of human gamma-secretase assessed as inhibition of amyloid beta (1 to 42 residues) production by ELISAMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50:  83nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair