BDBM50364682 CHEMBL1951471::US8785634, 82

SMILES FC(F)(F)Oc1ccc(cc1)S(=O)(=O)N1CCC2(CC1)OC(c1cccnc21)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=AXYFDQZWQQKJKV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50364682   

TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50364682(CHEMBL1951471 | US8785634, 82)
Affinity DataIC50:  1.60nMAssay Description:The potency of compounds of formula I against PrCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PrCP inhibit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364682(CHEMBL1951471 | US8785634, 82)
Affinity DataIC50:  712nMAssay Description:Inhibition of PrCP in mouse plasma assessed as angiotensin 3 cleavage by whole serum shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364682(CHEMBL1951471 | US8785634, 82)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50364682(CHEMBL1951471 | US8785634, 82)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed