BDBM50364776 CHEMBL1952141::CHEMBL1952329
SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
InChI Key InChIKey=MHXGEROHKGDZGO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 53 hits for monomerid = 50364776
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of PIM1 (unknown origin) up to 120 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Inhibition of PIM1 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:Inhibition of PIM3 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 610nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 610nMAssay Description:Inhibition of PIM2 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of Pim1 kinase (unknown origin) using substrate S3 after 50 mins by HTRF assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Cylene Pharmaceuticals
Curated by ChEMBL
Cylene Pharmaceuticals
Curated by ChEMBL
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Competitive inhibition of PIM3 in presence of ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 363nMAssay Description:Competitive inhibition of PIM2 in presence of ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
Affinity DataIC50: 980nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PIM1 expressed in Escherichia coli using LKKRNRTLTV as substrate measured after 40 ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 363nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PIM1 in presence of ATP by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 363nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PIM1 using KKRNRTLTV as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation countingMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
Affinity DataIC50: 511nMAssay Description:Inhibition of human ERG incubated for 1 hr by Fluorescence polarization binding assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of human recombinant PIM3 using KKRNRTLTV as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 200nMAssay Description:Inhibition of PIM1 in human NCI-H1299 cells assessed as reduction in BAD phosphorylation at Ser-112 residue incubated for 4 hrs by ELISAMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of N-terminal GST tagged human recombinant FLT3 using abltide in presence of [gamma-33P]ATP by scintillation countingMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 618nMAssay Description:Inhibition of His tagged human recombinant PIM2 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of N-terminal 6-His tagged human recombinant PIM3 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based as...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of His tagged human recombinant PIM1 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 362nMAssay Description:Inhibition of human recombinant PIM2 using KKRNRTLTV as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length Pim-1 using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human Pim-3 using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 363nMAssay Description:Inhibition of human Pim-2 expressed in Escherichia coli cells using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of PIM1 (unknown origin) by coupled kinetic assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy
Curated by ChEMBL
Nri Institute Of Pharmacy
Curated by ChEMBL