BDBM50365224 CHEMBL1956291::US9238653, Table 5, Compound 29

SMILES Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2nc(nc2n1)C(F)(F)F

InChI Key InChIKey=PHPXBFMLYCJALY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50365224   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50365224(CHEMBL1956291 | US9238653, Table 5, Compound 29)
Affinity DataIC50:  130nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50365224(CHEMBL1956291 | US9238653, Table 5, Compound 29)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DHODH expressed in Escherichia coli BL21-DE3 using L-dihydroorotate as substrate by steady-state DCIP methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50365224(CHEMBL1956291 | US9238653, Table 5, Compound 29)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed