BDBM50369443 CHEMBL252953

SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1cccc2ccccc12)NC(=O)Cc1cncn1Cc1ccc(cc1)C#N

InChI Key InChIKey=MLBHNPAXTLCWTO-VCXVHRGASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50369443   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369443(CHEMBL252953)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369443(CHEMBL252953)
Affinity DataIC50:  0.150nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369443(CHEMBL252953)
Affinity DataIC50:  67nMAssay Description:Inhibition of [3H]GGPP incorporation into recombinant human Ha-RasCVLL by Geranylgeranyl transferase from bovine brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed