BDBM50370411 CINCHORINE::GNF-PF-3189

SMILES O[C@H]([C@H]1C[C@@H]2CC[N@]1C[C@@H]2C=C)c1ccnc2ccccc12

InChI Key InChIKey=KMPWYEUPVWOPIM-QAMTZSDWSA-N

Data  10 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50370411   

TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of partially purified cytochrome P450 2D6 1'-hydroxybufuralol formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  3.50E+3nMAssay Description:Apparent inhibitory constant (Ki) for Bufuralol 1'-hydroxylation by human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibitory effect on Bufuralol 1'-hydroxylation by human liver microsomes (Ki = apparent inhibition constant)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  9.30E+3nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  2.10E+4nMAssay Description:Binding affinity for cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataIC50: >6.79E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed