BindingDB PrimarySearch

BDBM50370453 LACTOSE::Lactose, anhydrous

SMILES: OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O

InChI Key: InChIKey=GUBGYTABKSRVRQ-DCSYEGIMSA-N

Data: 6 IC50 8 Kd

PDB links: 89 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50370453
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Galectin-3 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.30E+5	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development LLC Curated by ChEMBL					Assay Description Binding affinity to galectin-3 (unknown origin)				J Med Chem 57: 7819-37 (2014) Article DOI: 10.1021/jm500325k BindingDB Entry DOI: 10.7270/Q2JW8GH3
Janssen Research and Development LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-3 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a
FCFRP - USP Curated by ChEMBL					Assay Description Inhibition of human recombinant wild type galectin 3 after 60 mins by surface plasmon resonance immunosensor assay				Bioorg Med Chem 23: 3414-25 (2015) Article DOI: 10.1016/j.bmc.2015.04.044 BindingDB Entry DOI: 10.7270/Q2028T8V
FCFRP - USP Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-3 (Mus musculus)	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.22E+5	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Dissociation constant for mouse Galectin-3				Bioorg Med Chem Lett 15: 3344-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.084 BindingDB Entry DOI: 10.7270/Q2D79C6D
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-1 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	4.20E+5	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Binding affinity to galectin 1 at 20 degC by fluorescence polarization assay				J Med Chem 51: 8109-14 (2008) Article DOI: 10.1021/jm801077j BindingDB Entry DOI: 10.7270/Q29W0GDJ
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-3 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Binding affinity to galectin 3 at 20 degC by fluorescence polarization assay				J Med Chem 51: 8109-14 (2008) Article DOI: 10.1021/jm801077j BindingDB Entry DOI: 10.7270/Q29W0GDJ
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-8 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	6.20E+4	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Binding affinity to galectin 8N terminal domain at 20 degC by fluorescence polarization assay				J Med Chem 51: 8109-14 (2008) Article DOI: 10.1021/jm801077j BindingDB Entry DOI: 10.7270/Q29W0GDJ
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-3 (Mus musculus)	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Munich Curated by ChEMBL					Assay Description Inhibition of galectin-3 in C57BL/6 mouse jejunum using SK-5100 as substrate incubated for 30 mins by VAA staining based microscopic analysis				Bioorg Med Chem 25: 3158-3170 (2017) BindingDB Entry DOI: 10.7270/Q2PN9820
Ludwig-Maximilians-University Munich Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-1 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ du Qu£bec£ Montr£al Curated by ChEMBL					Assay Description Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutination assay				Bioorg Med Chem 16: 7811-23 (2008) Article DOI: 10.1016/j.bmc.2008.06.044 BindingDB Entry DOI: 10.7270/Q2HQ40TS
Universit£ du Qu£bec£ Montr£al Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-9 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Binding affinity to galectin 9N terminal domain at 0 degC by fluorescence polarization assay				J Med Chem 51: 8109-14 (2008) Article DOI: 10.1021/jm801077j BindingDB Entry DOI: 10.7270/Q29W0GDJ
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Galectin-7 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Binding affinity to galectin 7 at 0 degC by fluorescence polarization assay				J Med Chem 51: 8109-14 (2008) Article DOI: 10.1021/jm801077j BindingDB Entry DOI: 10.7270/Q29W0GDJ
Lund University Curated by ChEMBL					More data for this Ligand-Target Pair
Galectin-3 (Gallus gallus)	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.50E+6	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Munich Curated by ChEMBL					Assay Description Inhibition of binding of biotinylated truncated chicken galectin-3 to surface immobilized asialofetuin by solid phase assay				Bioorg Med Chem Lett 22: 313-8 (2011) Article DOI: 10.1016/j.bmcl.2011.11.010 BindingDB Entry DOI: 10.7270/Q2KP83BJ
Ludwig-Maximilians-University Munich Curated by ChEMBL					More data for this Ligand-Target Pair
Galectin-3 (Gallus gallus)	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10E+6	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Munich Curated by ChEMBL					Assay Description Inhibition of binding of biotinylated chicken galectin-3 to surface immobilized asialofetuin by solid phase assay				Bioorg Med Chem Lett 22: 313-8 (2011) Article DOI: 10.1016/j.bmcl.2011.11.010 BindingDB Entry DOI: 10.7270/Q2KP83BJ
Ludwig-Maximilians-University Munich Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-galactoside-binding lectin (Gallus gallus)	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Munich Curated by ChEMBL					Assay Description Inhibition of binding of biotinylated chicken galectin-1B to surface immobilized asialofetuin by solid phase assay				Bioorg Med Chem Lett 22: 313-8 (2011) Article DOI: 10.1016/j.bmcl.2011.11.010 BindingDB Entry DOI: 10.7270/Q2KP83BJ
Ludwig-Maximilians-University Munich Curated by ChEMBL					More data for this Ligand-Target Pair
Galectin-3 (Homo sapiens (Human))	BDBM50370453 (LACTOSE \| Lactose, anhydrous) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar	Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ du Qu£bec£ Montr£al Curated by ChEMBL					Assay Description Inhibition of recombinant galectin 3 in human O type red blood cells by hemagglutination assay				Bioorg Med Chem 16: 7811-23 (2008) Article DOI: 10.1016/j.bmc.2008.06.044 BindingDB Entry DOI: 10.7270/Q2HQ40TS
Universit£ du Qu£bec£ Montr£al Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)