BDBM50370573 COTININE::US10667515, Compound (S)-cotinine::US8609708, 91 Cotinine

SMILES CN1[C@@H](CCC1=O)c1cccnc1

InChI Key InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N

Data  1 KI  4 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50370573   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat frontal cortex membrane by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataIC50:  3.50E+7nMAssay Description:Inhibitory concentration against human cytochrome P450 2A6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A5(Mus musculus)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataIC50:  1.50E+6nMAssay Description:Inhibitory concentration against mouse cytochrome P450 2A5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetResistance to inhibitors of cholinesterase protein 3(Pig roundworm)
Iowa State University Research Foundation

US Patent
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataEC50: <1.00E+5nMAssay Description:Nematode eggs are isolated from fresh feces by centrifugation and flotation. The eggs are washed and inspected to confirm embryonation has not starte...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at alpha4beta2 nAChR in rat frontal cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataIC50: >4.00E+5nMAssay Description:The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataIC50:  5.40E+6nMAssay Description:Inhibitory concentration against recombinant human cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed