BDBM50371232 CARNOSIC ACID

SMILES CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O

InChI Key InChIKey=QRYRORQUOLYVBU-VBKZILBWSA-N

Data  4 KI  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50371232   

TargetB-cell CLL/lymphoma 9 protein(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to N-terminal FLAG tagged beta catenin (134 to 671 residues)/FLAG tagged BCL9 domain 2 (343 to 396 residues) (unknown origin) protei...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of CYP3A4 activity in human hepatocytes after 30 mins by liquid chromatography/tandem mass spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell CLL/lymphoma 9 protein(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  5.30E+3nMAssay Description:Competitive inhibition of wild type beta-catenin (unknown origin) expressed in Escherichia coli BL21 DE3 interaction with N-terminally biotinylated h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of CYP2C9 activity in human hepatocytes after 30 mins by liquid chromatography/tandem mass spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione S-transferase omega-1(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of GSTO1-1 (unknown origin) by 4-NPG substrate based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatenin beta-1(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to N-terminal FLAG tagged beta catenin alpha helix (H1 - 141 to 149 aa) of armadillo repeat domain (unknown origin) by STD/HSQC base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  240nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Homo sapiens (Human))
Sinhgad College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of pancreatic lipaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed