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BDBM50373814 CHEMBL270877

SMILES: COc1ccccc1N1CCN(C[C@H](C)Nc2nc(nc3ccccc23)C(F)(F)F)CC1

InChI Key: InChIKey=OPFJKGKEIAOBJQ-INIZCTEOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50373814   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysophosphatidic acid receptor Edg-4


(Homo sapiens)
BDBM50373814
PNG
(CHEMBL270877)
Show SMILES COc1ccccc1N1CCN(C[C@H](C)Nc2nc(nc3ccccc23)C(F)(F)F)CC1
Show InChI InChI=1S/C23H26F3N5O/c1-16(15-30-11-13-31(14-12-30)19-9-5-6-10-20(19)32-2)27-21-17-7-3-4-8-18(17)28-22(29-21)23(24,25)26/h3-10,16H,11-15H2,1-2H3,(H,27,28,29)/t16-/m0/s1
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at LPA2 expressed in RH7777 cells with Gi4-protein and aequorin by calcium mobilization assay


Bioorg Med Chem Lett 18: 1037-41 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.024
BindingDB Entry DOI: 10.7270/Q2JQ11W8
More data for this
Ligand-Target Pair