BDBM50387084 BMS-790052::DACLATASVIR
SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc(c[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1c[nH]c(n1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
InChI Key InChIKey=FKRSSPOQAMALKA-CUPIEXAXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50387084
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human liver CYP3A4More data for this Ligand-Target Pair
Affinity DataEC50: 0.0790nMAssay Description:Inhibition of HCV genotype 1a NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human liver CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+4nMAssay Description:Inhibition of human liver CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
Affinity DataEC50: 0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 1b assessed as decrease in viral replicationMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 2.92E+4nMAssay Description:Inhibition of human ERG by whole cell patch clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in subgenomic viral RNA replication treated for 2 d...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0320nMAssay Description:Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase rep...More data for this Ligand-Target Pair
Affinity DataEC50: 52.8nMAssay Description:Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase...More data for this Ligand-Target Pair
Affinity DataEC50: 49.4nMAssay Description:Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs b...More data for this Ligand-Target Pair
Affinity DataEC50: 0.412nMAssay Description:Inhibition of NS5A in HCV genotype 3a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase...More data for this Ligand-Target Pair
Affinity DataEC50: 0.115nMAssay Description:Inhibition of NS5A in patient-derived HCV genotype 3a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs b...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase rep...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 2a infected in human Huh7.5/J6/JFH1/EMCVIRES/hRlucNeo cells assessed as inhibition of replicon levels incubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in human HuH7.5/Con1/SG-Neo(I)-hRluc2aUb cells assessed as inhibition of replicon levels incubated for...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0500nMAssay Description:Inhibition of NS5A in Hepatitis C virus subtype 1a replicon assessed as reduction in viral replication using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO)...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00900nMAssay Description:Inhibition of NS5A in Hepatitis C virus subtype 1b replicon assessed as reduction in viral replication using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO)...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:Inhibition of NS5A in Hepatitis C virus subtype 2a replicon assessed as reduction in viral replication using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO)...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:Inhibition of Hepatitis C virus 2a NS5AMore data for this Ligand-Target Pair
Affinity DataEC50: 0.146nMAssay Description:Inhibition of Hepatitis C virus 3a NS5AMore data for this Ligand-Target Pair
Affinity DataEC50: 61nMAssay Description:Inhibition of Hepatitis C virus 1a NS5A Q30R mutantMore data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+3nMAssay Description:Inhibition of Hepatitis C virus 1a NS5A Q30E mutantMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0500nMAssay Description:Inhibition of Hepatitis C virus 1a H77 NS5AMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00900nMAssay Description:Inhibition of Hepatitis C virus 1b con1 NS5AMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0320nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human liver CYP2D6More data for this Ligand-Target Pair