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BDBM50387557 CHEMBL2057457::US9359372, DC037031

SMILES: COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O

InChI Key: InChIKey=OGNNKKYFJYJQEU-SFHVURJKSA-N

Data: 8 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50387557   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
KEGG

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US Patent
28.9 -10.4 56.4n/an/an/an/an/a30



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto...


US Patent US9359372 (2016)


BindingDB Entry DOI: 10.7270/Q2736PSP
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
KEGG

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UniChem

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Article
PubMed
28.9n/an/an/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells


Bioorg Med Chem 20: 4862-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.057
BindingDB Entry DOI: 10.7270/Q28P61K9
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
KEGG

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UniChem

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US Patent
28.9 -10.4n/an/an/an/an/a7.430



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were s...


US Patent US9359372 (2016)


BindingDB Entry DOI: 10.7270/Q2736PSP
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
KEGG

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Article
PubMed
29n/an/an/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter


Bioorg Med Chem 21: 856-68 (2013)


Article DOI: 10.1016/j.bmc.2012.12.016
BindingDB Entry DOI: 10.7270/Q2JD4Z4M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
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US Patent
161 -9.42n/an/an/an/an/a7.430



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were s...


US Patent US9359372 (2016)


BindingDB Entry DOI: 10.7270/Q2736PSP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
Reactome pathway
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UniChem

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US Patent
161 -9.42 456n/an/an/an/an/a30



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto...


US Patent US9359372 (2016)


BindingDB Entry DOI: 10.7270/Q2736PSP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
Reactome pathway
KEGG

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PC sid
UniChem

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Article
PubMed
161n/an/an/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiprone from human dopamine D2 receptor expressed in HEK293 cells


Bioorg Med Chem 20: 4862-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.057
BindingDB Entry DOI: 10.7270/Q28P61K9
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
Reactome pathway
KEGG

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
161n/an/an/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter


Bioorg Med Chem 21: 856-68 (2013)


Article DOI: 10.1016/j.bmc.2012.12.016
BindingDB Entry DOI: 10.7270/Q2JD4Z4M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
Reactome pathway
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Article
PubMed
n/an/a 456n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiprone from human dopamine D2 receptor expressed in HEK293 cells


Bioorg Med Chem 20: 4862-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.057
BindingDB Entry DOI: 10.7270/Q28P61K9
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50387557
PNG
(CHEMBL2057457 | US9359372, DC037031)
Show SMILES COc1cc2CCN3Cc4c(C)cc(C)cc4C[C@H]3c2cc1O
Show InChI InChI=1S/C20H23NO2/c1-12-6-13(2)17-11-21-5-4-14-9-20(23-3)19(22)10-16(14)18(21)8-15(17)7-12/h6-7,9-10,18,22H,4-5,8,11H2,1-3H3/t18-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
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UniChem

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Article
PubMed
n/an/a 56.4n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells


Bioorg Med Chem 20: 4862-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.057
BindingDB Entry DOI: 10.7270/Q28P61K9
More data for this
Ligand-Target Pair